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1) Boosting.
If your friend (not your 2nd controller!!) is on the other team in split-screen, you can easily just constantly keep killing his 2nd controller. This way you can boost off of other people's 2nd controller who are on the other team. You would have to invite him when you are in the lobby to have him be on the other team though.
2) Search & Destroy.
A) You could just have your 2nd controller kill himself and make it so your 2nd controller is spectating your teammates so you will be able to see where the enemy is on their screen as well. Unless they make it so that if one controller dies and the the other controller takes up the rest of the screen, this could be an issue.
B) You could be in split-screen mode in a S&

game by yourself, and you could play with one controller, and when you die you switch to the other controller making it so that you as a player have 2 lives.
3) "Bitch Controller" lol
A) If you need to be protected, you could just get your 2nd controller (the bitch controller) to help and plant claymores or something and protect your 1st controller.
B) If your first controller is low on ammo and has scavenger, you can just call your bitch controller in to kill themself, making a scavenger back pack appear. A fresh new gun will be available to pick up too.
C) If you are in an open area and you are exposed from many different angles, you can call in your bitch controller to zoom in with their sniper to patrol the area, showing you where enemies are to help guide you.
D) You can call in your bitch controller to distract the enemies if you are in a sticky situation or on a kill-streak.
This is all I can think of right now. Do you guys have anymore exploits/problems/advantages split-screen multiplayer might have? Personally I think it's a great feature!