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My friend said that it's possible. He said that it depends on the developer. He said that:
"if they did [checksum the patch]
you would have to checksum the patch
and write over the value in the checksums table"
I don't think it is, but it might be because when I was putting my modded patch back onto my HDD i got Hard Drive is Corrupted but this might have been because I done something wrong. But I know people who have done the same method as me and they have got it working fine.