Nate's voice in music will never be replaced.

He helped create the blueprint for West Coast hip-hop, and I was one of the lucky people who had the privilege to work with him and the honor to have him as a friend. Nate will be sorely missed. My condolences and prayers go out to his family and loved ones. -Eminem

"We lost a true legend n hip hop n rnb," Snoop tweeted. "One of my best friends n a brother to me since 1986 when I was a sophomore at poly high where we met."

Rapper/actor Xzibit experienced a boost in his profile after appearing on Snoop Dogg's "B Please," which featured singing from Nate Dogg. "We lost a [soldier], a father, a legend, a homie," Xzibit wrote. "My condolences go out to Ms. Ruth and the entire family. Celebrate #NateDogg #FOREVER."

Ludacris also benefitted from a catchy Nate Dogg hook on his 2001 song "Area Codes," which earned a Grammy Award nomination in the Best Rap/Sung Collaboration category. "There is a certain void in hip hop's heart that can never be filled," Luda tweeted. "Glad we got to make history together. RT @SnoopDogg: NATE DOGG."

50 Cent was traveling and heard about the news when he landed at his destination. "I just landed nate dog is dead damn," 50 tweeted. "GOD BLESS HIM R.I.P he meant a lot to west coast hiphop. Iv always been a fan of it." 50 also mentioned that although he wrote the hook Nate sings on "21 Questions," from his debut album, Get Rich or Die Tryin', he "needed nate to sing it for me. He had a way of making everything feel hard."

Other rappers expressed grief over Nate's death while also reminding fans of their collaborations. "R.I.P. TO MY HOMIE NATE DOGG!," Bay Area slang master E-40 tweeted, also providing a link to the video of his song "Nah, Nah," which featured Nate on its hook.

" my brother Nate Dogg," Cali lyricist Rass Kass wrote, while adding a link to his song "4 Much," featuring Bad Azz, Tash and Nate Dogg.

Nate's talents spanned the entire hip-hop nation: East Coast, West Coast and everywhere in between, as reflected by the tweets from his many collaborators.

"R.I.P. TO MY HOMEBOY NATE DOGG DPGC DOGG POUND GANGSTA 4 LIFE," fellow Long Beach native Daz Dillinger tweeted. Daz befriended Nate while they were working on "Deeez Nuuuts," from Dr. Dre's seminal album, The Chronic.

"R.I.P to the homie nate dogg, my condolences to his family," tweeted G-Unit's Lloyd Banks, who featured Nate on his songs "Warrior, Part 2" and "Til the End."

"Dam Big Homie nate dogg sleep well gangsta!!" Obie Trice tweeted. The Detroit rapper has a number of songs with Nate, including "Look in My Eyes" and "The Set Up."

Just to add from other Rap Legends:

personally, i like the new eminem better. his raps just flow smoother and its a side of him i like. hes starting to realize that he doesnt know what he has until its gone, and i think thats good

Damn a different side of Eminem I haven't seen.

I'm not even gonna bother trying to argue with you idiotic fools. EMINEM DA BEST!! loling hard at you guys. His flow is like every other faggot on the radio and his lyrics are on the same level as Lil Wayne. Lil Bow Wow has better lyrics than both of them and that's a statement. Also Eminem is far from the best he has nothing that makes him different from every rapper on the radio, you guys can't fathom what real rap is, and until you can I'm not even gonna bother arguing with you guys.

Ever since he quit doin' drugs he's been a way better rapper, and shockingly enough to say, a better person.

As far as Nate Dogg, I never really listened to his stuff, but no one can deny the influence he had on the world of rap.

R.I.P. Nate Dogg