South Park makes an episode form scratch in 6 Days, while family guys and Simpsons take about 8-12 months per episode to be completed. That's what I love about south park, you never know what to expect and there is always small reference to stuff that happened in the last 24hours. Plus once you watch the commentary the episode just gets funner on second watch.
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Also here is a small documentary about how they make an episode form start to finish. You must login or register to view this content. You must login or register to view this content.