This is such a hard choice!
But I have to say Family guy. South Park's jokes are kind of like, interpreted (even though they are EXTREMELY obvious haha ) But Family guy will just come right out and say it. But I <3 South Park. MYSTERION FTW.
Personally I think that Family guy is just to epic. A dog who loves to drink , A baby who is super evil , Meg who everybody hates , Peter who is just complety random , Cleveland and Chris and diggity diggity