typical profit on a physical item is about 25-35%. So you figure the cost of a MW2 disc:
$60 retail
retailer purchase from Activision at aprox $40 a disc making $18 profit
Activision makes aprox $12.5 per disc. The rest of the $60 ($29.50) is te cost of production, marketing and writing the content for the game.
This of course is going to fluccuate signficantly based on the quantity the retailer is buying and the production costs might be off a bit. This is just a fair estimate of what the break down is.
If you're interested in finding more out on the sales and profits of a company... check out the 10k statement for ATVI (Activision). they're a US public company so the info is available for you to read.

---------- Post added at 03:55 PM ---------- Previous post was at 03:54 PM ----------
ROI is a major part of business. Actually its the most important part.

Where is the link for this info you posted?