If anyone's interested - these natives were added to the game in patch 3.50.1:
Originally posted by another user
MemoryRegionCheckFn
MemoryRegionCheckDllName
MemoryRegionCheckMemoryHash
rage::FallbackMachineHashStrategy
rage::netKeyExchangeAnswer
rage::netKeyExchangeOffer
In short- they check for injected .dll files or injected code and report back to R*. This also affects singleplayer.